La premiére description d'un patient présentant le 'syndrome de Noonan 'est faite par Koblinsky en 1883..
Cardiologue Pédiatre née le 28 Octobre 1921 à Burlington dans le Vermont. Le Docteur Jacqueline Noonan est cardiologue-pédiatre , diplomé à Boston en 1956.


Quand elle commence son travail à l'université de l'Iowa (USA) en tant que premiére cardiologue pédiatre, elle se pose la question: "pourquoi certains enfants ont une cardiopathie congènitale ainsi que d'autres anomalies". Elle a étudié 833 patients atteints de cardiopathie congènitale ,en recherchant d'autres anomalies congènitales, et en 1962 elle redige: " Malformations non-cardiaques associées chez les enfants ayant une malformation cardiaque congènitale ".

Elle décrit 9 enfants qui en plus de leur cardiopathie congènitale ont des visages caractéristiques.
Filles et Garçons sont pareillement affectés, et les chromosomes sont apparemment 'normaux'.

C'est le DR John Opek, un ex-étudiant du DR Noonan, qui a commencé la premiére fois à appeler ce syndrome " symdrome de Noonan " quand il vit des enfants qui ressemblaient à ceux décrits par le Docteur Jacqueline Noonan .

Plus tard Le DR Noonan redigea " Hypertelorism with Turner Phenotype



En 1971 au colloque des maladies cardiovasculaires, le nom de 'syndrome de Noonan' fut officiellement reconnu.

    jacqueline NOONAN

American paediatric cardiologist, born October 28, 1921, Burlington, Vermont.
Dr Noonan is a paediatric cardiologist and paediatrician, who qualified in Boston in 1956.

When she subsequently began work at the University of Iowa as their first paediatric cardiologist, she became interested in why some children had congenital heart disease and other abnormalities that may occur with it.
She studied 833 patients at the congenital heart disease clinic, looking for other congenital abnormalities, and in 1962 presented a paper:
"Associated non-cardiac malformations in children with congenital heart disease".

This described 9 children who in addition to congenital heart disease had characteristic faces, chest deformities and short stature. Both males and females were found to be similarly affected, and the chromosomes were apparently 'normal'.

It was Dr John Opek, an ex-student of Dr Noonan, who first began to call the condition "Noonan Syndrome" when he saw children who looked like those whom Dr Noonan had described.
Dr Noonan later produced a paper entitled "Hypertelorism with Turner Phenotype", and in 1971 at the Symposium of Cardiovascular defects, the name 'Noonan Syndrome' became officially recognised.